Korbicz, Józef - red. ; Uciński, Dariusz - red.
The paper deals with the analysis of signaling pathways aimed at uncovering new regulatory processes regulating cell responses. First, general issues of comparing simulation and experimental data are discussed, and various aspects of data normalization are covered. Then, a model of a particular signaling pathway, induced by Interferon-?, is briefly introduced. It serves as an example illustrating how mathematical modeling can be used for inferring the structure of a regulatory system governing the dynamics of intracellular processes. ; In this pathway, experimental results suggest that a hitherto unknown process is responsible for a decrease in the levels of one of the important molecules used in the pathway. Then, equilibrium points of the model are analyzed, allowing the rejection of all but one explanation of the phenomena observed experimentally. Numerical simulations confirm that the model can mimic the dynamics of the processes in the pathway under consideration. Finally, some remarks about the applicability of the method based on an analysis of equilibrium points are made.
Zielona Góra: Uniwersytet Zielonogórski
AMCS, Volume 20, Number 4 (2010) ; click here to follow the link
Biblioteka Uniwersytetu Zielonogórskiego
Sep 7, 2021
Aug 16, 2018
|Coupled analytical and numerical approach to uncovering new regulatory mechanisms of intracellular processes||Sep 7, 2021|
Fujarewicz, Krzysztof Korbicz, Józef - red. Uciński, Dariusz - red.
Śmieja, Jarosław Świerniak, Andrzej (1950- ) Kimmel, Marek - red. Lachowicz, Mirosław - red. Świerniak, Andrzej - red.
Pająk, Iwona Jurczak, Paweł - red.
Penkov, Igor Aleksandrov, Dmitri Jurczak, Paweł - red.
Akbari, Karim Moayeri, Hamid Ghassemi, Hassan Jurczak, Paweł - red.
Chin, Cheng Siong Lau, Micheal Wai Shing Low, Eicher Seet, Gerald Gim Lee Korbicz, Józef - red. Uciński, Dariusz - red.
Dettmann, Kai-Uwe Söffker, Dirk Korbicz, Józef - red. Uciński, Dariusz - red.
Nowogoński, Ireneusz Golik, Karolina Greinert, Andrzej - red. Kołodziejczyk, Urszula - red.