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		<identifier>oai:zbc.uz.zgora.pl:78704</identifier>
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<dc:title xml:lang="pl"><![CDATA[Model based analysis of signaling pathways]]></dc:title>
<dc:creator><![CDATA[Śmieja, Jarosław]]></dc:creator>
<dc:subject xml:lang="pl"><![CDATA[signaling pathways]]></dc:subject>
<dc:subject xml:lang="pl"><![CDATA[dynamical systems]]></dc:subject>
<dc:subject xml:lang="pl"><![CDATA[systems biology]]></dc:subject>
<dc:subject xml:lang="pl"><![CDATA[interferon-beta]]></dc:subject>
<dc:description xml:lang="pl"><![CDATA[The paper is concerned with application of mathematical modeling to the analysis of signaling pathways. Two issues, deterministic modeling of gene transcription and model-driven discovery of regulatory elements, are dealt with. First, the biological background is given and the importance of the stochastic nature of biological processes is addressed. The assumptions underlying deterministic modeling are presented. Special emphasis is put on describing gene transcription.]]></dc:description>
<dc:description xml:lang="pl"><![CDATA[A framework for including unknown processes activating gene transcription by means of first-order lag elements is introduced and discussed. Then, a particular interferon-? induced pathway is introduced, limited to early events that precede activation of gene transcription. It is shown how to simplify the system description based on the goals of modeling. Further, a computational analysis is presented, facilitating better understanding of the mechanisms underlying regulation of key components in the pathway. The analysis is illustrated by a comparison of simulation and experimental data.]]></dc:description>
<dc:publisher><![CDATA[Zielona Góra: Uniwersytet Zielonogórski]]></dc:publisher>
<dc:contributor><![CDATA[Kasiński, Andrzej - ed.]]></dc:contributor>
<dc:contributor><![CDATA[Ponulak, Filip - ed.]]></dc:contributor>
<dc:date><![CDATA[2008]]></dc:date>
<dc:type xml:lang="pl"><![CDATA[artykuł]]></dc:type>
<dc:identifier><![CDATA[http://www.zbc.uz.zgora.pl/repozytorium/Content/78704/AMCS_2008_18_2_3.pdf]]></dc:identifier>
<dc:identifier><![CDATA[https://zbc.uz.zgora.pl/repozytorium/dlibra/publication/88465/edition/78704/content]]></dc:identifier>
<dc:identifier><![CDATA[oai:zbc.uz.zgora.pl:78704]]></dc:identifier>
<dc:source xml:lang="pl"><![CDATA[AMCS, volume 18, number 2 (2008)]]></dc:source>
<dc:source xml:lang="pl"><![CDATA[https://www.amcs.uz.zgora.pl/?action=papers&issue=32]]></dc:source>
<dc:language><![CDATA[eng]]></dc:language>
<dc:relation><![CDATA[oai:zbc.uz.zgora.pl:publication:88465]]></dc:relation>
<dc:rights xml:lang="pl"><![CDATA[Biblioteka Uniwersytetu Zielonogórskiego]]></dc:rights>
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