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<dc:title xml:lang="pl"><![CDATA[Fractal model of transdermal drug delivery]]></dc:title>
<dc:creator><![CDATA[Walicka, Anna]]></dc:creator>
<dc:creator><![CDATA[Iwanowska-Chomiak, Beata]]></dc:creator>
<dc:subject xml:lang="pl"><![CDATA[drug delivery]]></dc:subject>
<dc:subject xml:lang="pl"><![CDATA[human skin]]></dc:subject>
<dc:subject xml:lang="pl"><![CDATA[epidermis]]></dc:subject>
<dc:subject xml:lang="pl"><![CDATA[fractal models]]></dc:subject>
<dc:description xml:lang="pl"><![CDATA[Skin, separating the vital organs of a human body, is a desirable route for drug delivery. However, the intact skin is normally permeable only for drug molecules with a low molecular weight. The stratum corneum (SC), being the outermost layer of the skin and the epidermis being the second - more permeable - layer of the skin, play an essential function in transdermal drug delivery. Physical and chemical methods of skin poration are used to enhance transdermal drug delivery.]]></dc:description>
<dc:description xml:lang="pl"><![CDATA[Each poration leads to an irregular system of pores which are connected with a system of micro-capillaries passing through the epidermis. Both the systems by their irregularity form a fractal porous matrix. Drugs administrated by this matrix can be either suspensions and solutions or creams and gels, therefore they have to be modelled as non-Newtonian fluids. To analyse the fluid flow through the porous matrix the model of the epidermis is assumed as gobbet-and-mortar with the tortuous mortar of variable thickness and after transition from the mortar to the tube one considered classical and fractal capillary flows of selected non-Newtonian fluids.]]></dc:description>
<dc:description xml:lang="pl"><![CDATA[Fractal expressions for the flow rate, velocity and permeability of fluids flow in a porous matrix are derived based on the fractal properties of the epidermis and capillary model. Each parameter in the proposed expressions does not contain any empirical constant and has a clear physical meaning and the proposed fractal models relate the flow properties of considered fluids with the structural parameters of the epidermis as a porous medium. The presented analytical expressions will help understand some of the physical principles of transdermal drug delivery.]]></dc:description>
<dc:publisher><![CDATA[Zielona Góra: Uniwersytet Zielonogórski]]></dc:publisher>
<dc:contributor><![CDATA[Jurczak, Paweł - red.]]></dc:contributor>
<dc:date><![CDATA[2018]]></dc:date>
<dc:type xml:lang="pl"><![CDATA[artykuł]]></dc:type>
<dc:format xml:lang="pl"><![CDATA[application/pdf]]></dc:format>
<dc:identifier><![CDATA[http://www.zbc.uz.zgora.pl/repozytorium/Content/73003/10.2478_ijame-2018-0056.pdf]]></dc:identifier>
<dc:identifier><![CDATA[https://zbc.uz.zgora.pl/repozytorium/dlibra/publication/80194/edition/73003/content]]></dc:identifier>
<dc:identifier><![CDATA[oai:zbc.uz.zgora.pl:73003]]></dc:identifier>
<dc:source xml:lang="pl"><![CDATA[IJAME, volume 23, number 4 (2018)]]></dc:source>
<dc:language><![CDATA[eng]]></dc:language>
<dc:relation><![CDATA[oai:zbc.uz.zgora.pl:publication:80194]]></dc:relation>
<dc:rights xml:lang="pl"><![CDATA[Biblioteka Uniwersytetu Zielonogórskiego]]></dc:rights>
<dc:rights xml:lang="pl"><![CDATA[CC 4.0]]></dc:rights>
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