Creator:

Verdiere, Nathalie ; Denis-Vidal, Lilianne ; Joly-Blanchard, Ghislaine ; Domurado, Dominique

Contributor:

Beliczyński, Bartłomiej - red.

Title:

Identifiability and estimation of pharmacokinetic parameters for the ligands of the macrophagemannose receptor

Subtitle:

Intelligent Control and Signal Processing

Group publication title:

AMCS, Volume 15 (2005)

Subject and Keywords:

nonlinear systems ; identifiability ; parameter estimation ; biological applications

Abstract:

The aim of this paper is numerical estimation of pharmacokinetic parameters of the ligands of the macrophage mannosereceptor, without knowing "a priori" the values of these parameters. However, it first requires a model identifiability analysis, which is done by applying an algorithm implemented in a symbolic computation language. It is shown that this step can lead to a direct numerical estimation algorithm. In this way, a first estimate is computed from noisy simulated observations without a priori parameter values. Then the resulting parameter estimate is improved by using the classical least-squares method.

Publisher:

Zielona Góra: Uniwersytet Zielonogórski

Date:

2005

Resource Type:

artykuł

Pages:

517-526

Source:

AMCS, Volume 15, Number 4 (2005) ; click here to follow the link

Language:

eng

Rights:

Biblioteka Uniwersytetu Zielonogórskiego